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These studies did not provide comparison to younger subjects. Fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. Following prolonged therapy in high doses, abrupt discontinuation of TCAs, including imipramine, could lead to certain cholinergic symptoms such as nausea, vomiting, waar te koop imipramine or diarrhea. Hypomanic or manic episodes may occur, particularly in patients with cyclic disorders.

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