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Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor. Patients treated vigorously with diuretics or on hemodialysis see WARNINGS: Hypotension in Volume- or Salt-depleted Patients. The side effects see WARNINGS of irbesartan are generally rare and apparently independent of those of hydrochlorothiazide are mixture of dose-dependent primarily hypokalemia and dose-independent phenomena. Angiotensin II receptor antagonists, like irbesartan, and angiotensin converting enzyme ACE inhibitors exert similar effects on the renin-angiotensin system. The observed effects are believed to be late gestational effects of the drug. Dilutional hyponatremia may occur in edematous patients in hot appropriate therapy is water restriction, rather than administration of salt except avalide avalide kopen in rare instances when the hyponatremia is life-threatening.

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