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It possesses no acidic properties, in contrast to its barbiturate analog. 98 Primidone, like phenobarbital and the benzodiazepines, can also cause sedation in the newborn and also withdrawal within primidone kjope primidone the first few days of phenobarbital is the most likely out of all of them to do that. Subscribe to our popular newsletter containing regular roundup of medication news, alerts and new drug approvals. Unlike primidone, phenobarbital is considered controlled substance. What other drugs will affect primidone? There may be other drugs that can interact with primidone. 126 The available brands include Mysoline Canada, 127 Ireland, 128 Japan, 129 the United Kingdom, 130 and the United States 127 Prysoline Israel, Rekah Pharmaceutical Products, Ltd.